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S-Tier: The True Behemoths
1. Azrath the Eternal Warden
Azrath is a formidable demon who has control over time, presenting a unique challenge in battle. His most fearsome ability, "Time Warp," slows down the player's actions while accelerating his own, requiring players to depend on precise timing and reflexes to evade his devastating attacks. Additionally, he summons minions that pursue the player, adding another layer of difficulty. Defeating Azrath grants players some of the best Diablo 4 Items , including exclusive Legendary gear that can significantly change build strategies and enhance overall gameplay.

2. Therash the Shattered God
As one of the most visually impressive bosses in Diablo 4, Therash features remarkable mechanical depth alongside powerful elemental abilities. His multi-phase fight involves shifting between forms that necessitate different strategies. In the initial phase, he employs strong frost-based attacks that freeze the ground, complicating movement. In his final phase, he unleashes explosive shockwaves capable of eliminating players in mere seconds.

A-Tier: Mastering the Mechanics
1. Regaul the Infernal Sovereign
Regaul is a natural force, with attacks that can incinerate players caught unprepared. His fire-based moves are unpredictable, and he can summon fiery minions that complicate dodging his attacks. Despite these challenges, Regaul presents a tactical fight that rewards precision and timing. His loot generally consists of high-tier items in Diablo 4, including powerful gear that enhances both offense and defense. Players who succeed in defeating him receive gear that can significantly boost their survivability and damage output, making the encounter worthwhile.

2. Isathra the Ravager
Isathra is a massive, multi-headed beast that inflicts both poison and physical damage simultaneously. Players must navigate an arena filled with environmental hazards while avoiding her rapid poison breath. The key to overcoming Isathra lies in addressing her heads individually, each representing different damage types. While not as challenging as the S-Tier bosses, Isathra’s substantial health pool and ability to summon reinforcements make her a formidable opponent.

B-Tier: Moderate Difficulty, Manageable for Most Players
1. Rexmar the Deathbringer
Rexmar is a melee-focused boss that relies on powerful physical attacks and occasionally summons swarms of minions to overwhelm players. His attacks are strong but predictable, allowing players to avoid most damage by staying mobile. The most challenging aspect of this encounter is managing the minion spawns. These items can be essential for refining your character’s build and enhancing defenses.

2. Azgaroth the Butcher King
Azgaroth is a ruthless, straightforward boss that primarily relies on quick, punishing melee attacks. Although his damage output is significant, his attack patterns are relatively easy to predict, making him a suitable choice for players seeking a solid challenge without the overwhelming mechanics of higher-tier bosses. His loot is decent, providing valuable u4gm Diablo 4 Items  that can be used to upgrade armor or craft better gems, which are vital for progressing through Season 9.